Inside the LSD-bound crystal framework, the facet chain of the lid residue L209EL2 sorts intensive hydrophobic contacts with both LSD and bordering residues in TMs III, IV, and V (Figure 4C). When the lid moved apart to reveal the binding pocket in simulation, quite a few of such contacts broke. https://hylistings.com/story20796211/lsd-crystal-can-be-fun-for-anyone