Epidural clonidine utilised as an adjunct to local anesthetics has 3 different mechanisms of action. Initially, the stimulation of alpha-2-receptors during the dorsal horn lowers pain transmission. Next, clonidine can cause local vasoconstriction that boundaries vascular removing of regional epidural anesthetics. Applies to clonidine: oral pill, oral pill prolonged https://bookmarkuse.com/story19582911/onolidine-no-further-a-mystery