Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors from the central nervous system, conolidine modulates alternate molecular targets. A Science Advances research discovered that conolidine interacts With all the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://titusouvwv.madmouseblog.com/18349059/helping-the-others-realize-the-advantages-of-alternative-natural-pain-relief-to-replace-traditional-painkillers